The GADD45B antibody - middle region (ARP48346_P050) from Aviva Systems Biology is a Rabbit Polyclonal antibody. This antibody recognizes Human, and Mouse antigen. The GADD45B antibody - middle region (ARP48346_P050) has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
The function of GADD45B is involved in the regulation of growth and apoptosis.This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications